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Cefixime
Intended Dose:
Drug Pharmacology

Third generation cephalosporins
Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms:
  1. Uncomplicated urinary tract infections caused by Escherichia coliand Proteus mirabilis,
  2. Otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes,
  3. Pharyngitis and tonsillitis caused by S. pyogenes,
  4. Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and
  5. Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Acute Exacerbation of Chronic Bronchitis caused by Streptococcus Pneumoniae
Acute Exacerbations of Chronic Bronchitis caused by Haemophilus Influenzae
Acute maxillary sinusitis caused by M. catarrhalis
Community Acquired Pneumonia (CAP)
Gonorrhea of anus
Lyme Disease
Otitis media bacterial
Salmonella Infections
Salmonella Typhi Infection
Shigella Infection
Streptococcal Pharyngitis
Streptococcal tonsillitis
Uncomplicated Urinary Tract Infections
Bacterial rhinosinusitis
Uncomplicated Gonorrhea 
Safety and effectiveness of Cefixime in children aged less than six months old have not been established.
Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.